That argument was amplified Tuesday when news broke that two top vaccine officials said they would retire this fall. Marion Gruber, who leads the Office of Vaccines Research and Review, is scheduled to depart the FDA at the end of October. Philip Krause, Gruber’s deputy, is expected to leave the agency in November. The two career officials have decades of experience in vaccines and have helped steer the agency’s efforts through a demanding period that began 18 months ago with the pandemic. Their planned departures were first reported by BioCentury, an industry publication.